Intermediate Layer Contribution in Placental Tissue
Annelise Roy & Sarah Griffiths, PhD
The Use of a Dehydrated Complete Human Placental Membrane Allograft for Mohs Surgical Defects of the Nose
Placental membrane (PM) allografts are commonly used to treat chronic wounds. Native PM is composed of an amnion, chorion, and intermediate layer (IL) that contain matrix structures and regulatory components beneficial in wound healing. Historically, commercially available allografts were composed of only one or two layers of the PM. To maximize the conserved material in PM allografts, a dehydrated complete human placental membrane (dCHPM) allograft processed using the Clearify™ process was developed. Histological and proteomic characterization comparing dCHPM allografts with native PM demonstrated that the majority of matrix structures and regulatory proteins are retained in dCHPM allografts...
Background: Repair options for Mohs surgical defects include primary closure, flap or graft, or healing by second intention. These options may not be optimal in all cases. A dehydrated complete human placental membrane (dCHPM) allograft may serve as an alternative repair option. Objective: To assess the aesthetic and functional outcomes of an alternative repair technique for Mohs surgical defects of the nose. Methods: Twenty patients with Mohs surgical defects of the nose repaired with a dCHPM allograft were retrospectively identified. Photographs were used to demonstrate surgical technique and outcomes. Two blinded observers evaluated final outcomes using the Patient...
Placental Tissues as Biomaterials in Regenerative Medicine