Why Placental Tissue?

The use of placental tissues in wound care has been documented in medical texts since the early 20th century.¹ These tissues encompass the placental disc, umbilical cord, amniotic fluid, and placental membrane (PM), all of which play a role in supporting fetal development.

There are three distinct layers that make up the native PM (amnionThe amnion layer is the innermost layer of the PM. This layer provides tensile strength and acts as a fibrous skeleton.², intermediate layerThe intermediate layer exists between the amnion and chorion layers and is rich in collagens, proteoglycans, and glycosaminoglycans, like hyaluronic acid.², and chorionThe chorion layer is the outermost, and commonly the thickest layer of the PM. It contributes to elasticity and membrane stability.²). These three layers function together to create the ideal protective covering and barrier between the mother and the fetus.² Each layer contributes distinct mechanical characteristics and components, such as proteins, growth factors, cytokines, enzyme inhibitors, proteoglycans, and glycosaminoglycans, to the membrane as a whole.

Most placental membrane-derived products are single or dual-layer allografts (usually amnion and/or chorion layers). StimLabs developed the first allograft to retain all three layers of the membrane. While some delaminated tri-layer products have also been recently introduced, StimLabs has a unique patented technology that includes never delaminatingDelamination of the layers risks the removal of native components as well as key structural and functional proteins.²  the tissue during processing.