The first complete human placental membrane allograft2
Revita is the first dehydrated complete human placental membrane allograftA tissue graft from a donor of the same species as the recipient but not genetically identical.1 that preserves all three layers of the native tissue.2 Preserving all three layers of the placental membrane allows Revita to retain the maximum concentration of components naturally found in the tissue.2,3 Revita is designed to be used as a wound covering and/or barrier membrane, over acute and chronic wounds.
Product Features & Benefits
Why is Revita unique?
The use of placental tissues in wound care has been documented in medical texts since the early 20th century.4 There are three distinct layers that make up this membrane: the amnion layerThe amnion layer is the innermost layer of the placental membrane. This layer provides tensile strength and acts as a fibrous skeleton.3, intermediate layerThe intermediate layer exists between the amnion and chorion layers and is rich in collagens, proteoglycans, and glycosaminoglycans, like hyaluronic acid.3, and chorion layerThe chorion layer is the outermost, thickest layer of the placental membrane. It contributes to elasticity and membrane stability.3.3 The three layers function together to create the ideal protective covering and barrier between the mother and the fetus.
While most placenta-based products provide single or dual layer allografts, StimLabs has developed the first membrane allograft to retain all three layers of the membrane, including the intermediate layer.2 The preserved intermediate layer is a vital part of the membrane barrier property intrinsic to the tissue. The layer contributes to the overall composition of the allograft, containing extracellular matrix components like collagenProvides strength and structural resistance to degrading enzymes in native placental tissue.3, proteoglycansPromotes tissue hydration in native placental tissue.3, and glycosaminoglycans, like hyaluronic acidProvides lubricating and elastic properties in native placental tissue.3.3
Where is Revita commonly applied?
Acute and chronic wounds such as:
- Venous Ulcers
- Diabetic Ulcers
- Traumatic Wounds
- Dermatologic Wounds
- Surgical Wounds
- Post-amputation Wounds
- Burns
- Post-radiation Wounds or Burns
How do we retain these beneficial components?
Clearify™ is a unique, patented processing approach to placental tissue that maximizes the retention of desired structural components, while effectively cleaning and terminally sterilizing the graft.2 The Clearify™ processing method, originally created specifically for Revita, is designed to preserve all three layers of the placental membrane.2 The Revita allografts are freeze-dried and never delaminated, meaning that in processing, the layers aren’t pulled apart. This protects key components and natural architecture from being stripped away or damaged as the product is processed.2
Product Information
Sheet format | Shelf-stable for up to five (5) years
Sizes | 15 mm, 2x2 cm, 2x3 cm, 4x4 cm, 4x6 cm, 2x12 cm, 6x6 cm, 6x8 cm
Product Codes | RV-0015, RV-2020, RV-2030, RV-4040, RV-4060, RV-0212, RV-6060, RV-6080
What to Expect
For more application and use information, please see the Instructions for Use.
- Oxford Languages.
- Data on file. The data is reported as an average.
- Roy, A., & Griffiths, S. (2020). Intermediate Layer Contribution in Placental Membrane Allografts. Journal of Tissue Engineering and Regenerative Medicine, 14(8), 1126–1135.
- S Silini, A. R., Cargnoni, A., Magatti, M., Pianta, S., & Parolini, O. (2015). The Long Path of Human Placenta, and Its Derivatives, in Regenerative Medicine. Frontiers in bioengineering and
biotechnology, 3, 162. https://doi.org/10.3389/fbioe.2015.0016