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A fenestrated complete human placental membrane allograft

Cogenex, a fenestrated dehydrated complete human placental membrane (dCHPM) allograft, is designed for use as a selective barrier to protect chronic and acute wounds from the surrounding environment. Fenestration of the allograft creates a selective barrier with channels that allow wound fluid to drain.1 Cogenex preserves all three layers of the placental membrane and maintains the 3D physiologic architecture of the natural barrier membrane.2

Product Features & Benefits

Provides triple-layer protection by preserving the three layers of the native placental membrane
Thick architecture with fenestrations
Excellent application and handling properties2
ResorbableGradually breaks down and absorbs naturally into the body1 selective barrier

Why is Cogenex unique?

While most placental membrane-based products provide single or dual layer allografts, StimLabs has developed membrane allografts to retain all three layers of the membrane, including the intermediate layerThe intermediate layer exists between the amnion and chorion layers and is rich in collagens, proteoglycans, and glycosaminoglycans, like hyaluronic acid.3.2 The intermediate layer is a vital part of the membrane barrier property intrinsic to the tissue. The layer contributes to the overall composition of the allograft, containing extracellular matrix components like collagenProvides strength and structural resistance to degrading enzymes in native placental tissue.3, proteoglycansPromotes tissue hydration in native placental tissue.3, and glycosaminoglycans, like hyaluronic acidProvides lubricating and elastic properties in native placental tissue.3.3

Cogenex is presented in a fenestrated configuration for various applications. These fenestrations are made through the full thickness of the tissue. Cogenex acts as a selective barrier to offer protection to the wound from the surrounding environment while allowing wound fluid to drain. The wound fluid present in chronic wounds has been found to have high levels of proteases, which have an adverse effect on these wounds and their ability to resolve.4

Where is Cogenex commonly applied?

Acute and chronic wounds such as:

  • Venous Ulcers
  • Diabetic Ulcers
  • Traumatic Wounds
  • Dermatologic Wounds
  • Surgical Wounds
  • Post-amputation Wounds
  • Burns
  • Post-radiation Wounds or Burns
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How do we retain these beneficial components?2

Clearify is a unique, patented processing approach to placental tissue that maximizes the retention of desired structural components, while effectively cleaning and terminally sterilizing the graft. The Clearify processing method is designed to preserve all three layers of the placental membrane. The Cogenex allografts are freeze-dried, fenestrated, and are never delaminated, meaning the layers aren’t pulled apart in processing. This protects key structural components and the natural architectural features from being stripped away or damaged as the product is processed.

Cogenex Box

Product Information

Sheet format   |   Shelf-stable for up to five (5) years

Sizes   |   2x3 cm, 4x4 cm, 6x8 cm

Product Codes    |   CG-2030, CG-4040, CG-6080

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What to Expect

For more application and use information, please see the Instructions for Use.

  1. Tarar, M. N., Mehmood, F., Riaz, A., Khan, Z., Khalid, K., & Sher, F. (2016). Transversely meshed skin grafting for aesthetically sensitive areas. Annals of King Edward Medical University, 12(1). https://doi.org/10.21649/akemu.v12i1.849
  2. Data on file.
  3. Roy, A., & Griffiths, S. (2020). Intermediate Layer Contribution in Placental Membrane Allografts. Journal of Tissue Engineering and Regenerative Medicine, 14(8), 1126–1135.
  4. Widgerow AD. Chronic wound fluid--thinking outside the box. Wound Repair Regen. 2011 May-Jun;19(3):287-91. doi: 10.1111/j.1524-475X.2011.00683.x. Epub 2011 Apr 21. PMID: 21518088.

Patents: www.stimlabs.com/patents