Why Placental Tissue?

The use of placental tissues in wound care has been documented in medical texts since the early 20th century.1 The three distinct layers that make up the placental membrane (amnionThe amnion layer is the innermost layer of the placental membrane. This layer provides tensile strength and acts as a fibrous skeleton.3, intermediate layerThe intermediate layer exists between the amnion and chorion layers and is rich in collagens, proteoglycans, and glycosaminoglycans, like hyaluronic acid.3, and chorion)The chorion layer is the outermost, thickest layer of the placental membrane. It contributes to elasticity and membrane stability.2 function together to create the ideal protective covering and barrier between the mother and the fetus.2 

While most placental membrane-derived products provide single or dual-layer allografts, StimLabs has developed the first membrane allograft to retain all three layers of the membrane, including the intermediate layer, while never delaminating the native tissue.3

The Native Intermediate Layer 2

Located between the amnion and chorion, the native intermediate layer is a vital part of the placental membrane.

Acts as a cushion

Can account for at least 40% of membrane thickness

Contains proteoglycans and glycosaminoglycans, such as HA

Contains collagens I, III, IV

3 Layer illustration labeled

Histology Analysis

Stains
Histological section of native unprocessed PM stained with H&E, showing the amnion, intermediate layer, and chorion morphology, cell nuclei, and extracellular matrix content.
Histological section of native unprocessed PM stained with Maisson's Trichrome showing collagen content.
Histological section of native unprocessed PM stained with Alcian Blue showing mucopolysaccharides content.
What is placental tissue?

Placental tissues encompass all the tissues which support fetal development, including the placenta, placental membrane, umbilical cord, and amniotic fluid. Since the 1990s there has been renewed interest in the use of these tissues as a raw material for regenerative medicine applications.

Where does the placental tissue come from?

Beyond Birth is a birth tissue donation program of StimLabs that gives expectant mothers undergoing full-term cesarean deliveries the option to donate their birth tissues for transplant to patients facing a variety of medical conditions.

How does placental tissue work as a wound covering or barrier membrane?

Human placental membranes (PM) have been chosen as biological wound dressings for decades due to their unique structural and biochemical compositions.

1. Silini, A. R., Cargnoni, A., Magatti, M., Pianta, S., & Parolini, O. (2015). The Long Path of Human Placenta, and Its Derivatives, in Regenerative Medicine. Frontiers in Bioengineering and Biotechnology, 3(162). https://doi.org/10.3389/fbioe.2015.00162.

2. Roy, A., & Griffiths, S. (2020). Intermediate Layer Contribution in Placental Membrane Allografts. Journal of Tissue Engineering and Regenerative Medicine, 14(8), 1126–1135. https://doi.org/10.1002/term.3086.

3. Data on file.