Enverse TM
RevitaClear03_ClearBG(2)

A translucent complete human placental membrane allograft

Enverse is a translucent dehydrated complete human placental membrane allograftA tissue graft from a donor of the same species as the recipient but not genetically identical.1 optimized for use as a wound covering or barrier membrane. All three layers of the placental membrane tissue are preserved without disruption of the natural orientation during processing.2 Throughout the Clearify process, Enverse has been optimized to preserve extracellular matrix components, like collagens and glycoproteins, in a translucent, compact format.2

Product Features & Benefits

Contains collagen and hyaluronic acid2
Excellent product handling2
Thicker than the leading dual layer allograft2
Protective, resorbableGradually breaks down and absorbs naturally into the body1 wound covering
Translucent for increased application site visibility2
Compact for shallow tissue defects

Why is Enverse unique?

The use of placental tissues in wound care has been documented in medical texts since the early 20th century.4 There are three distinct layers that make up this membrane: the amnion layerThe amnion layer is the innermost layer of the placental membrane. This layer provides tensile strength and acts as a fibrous skeleton.3, intermediate layerThe intermediate layer exists between the amnion and chorion layers and is rich in collagens, proteoglycans, and glycosaminoglycans, like hyaluronic acid.3, and chorion layerThe chorion layer is the outermost, thickest layer of the placental membrane. It contributes to elasticity and membrane stability.3.The three layers function together to create the ideal protective covering and barrier between the mother and the fetus.

While most placental membrane-based products provide single or dual layer allografts, StimLabs has developed the first membrane allograft to retain all three layers of the membrane, including the intermediate layer.2 The preserved intermediate layer is a vital part of the membrane barrier property intrinsic to the tissue. The layer contributes to the overall composition of the allograft, containing extracellular matrix components like collagenProvides strength and structural resistance to degrading enzymes in native placental tissue.4, proteoglycansPromotes tissue hydration in native placental tissue.4, and glycosaminoglycans, like hyaluronic acidProvides lubricating and elastic properties in native placental tissue.4.4

Where is Enverse commonly applied?

Specialties Include:

  • Plastic Surgery
  • Vascular Surgery
  • General Surgery
  • Infectious Disease
  • Podiatry
  • Orthopedics
  • OB/GYN
  • Urology
  • Spine
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How do we retain these components?

Clearify is a unique, patented processing approach to placental tissue that maximizes the retention of desired structural components, while effectively cleaning and terminally sterilizing the graft.2 The Clearify™ processing method is designed to preserve all three layers of the placental membrane.2 The Enverse allografts are oven-dried, using our patented dehydration process, and never delaminated, meaning that the layers aren’t pulled apart in processing.2 This protects key structural components and the natural architecture from being stripped away or damaged as the product is processed.2

Enverse Front Mockup

Product Information

Sheet format   |   Shelf-stable for up to five (5) years

Sizes   |   15 mm, 2x3 cm, 4x4 cm, 4x6 cm, 6x8 cm

Product Codes    |    EN-0015, EN-2030, EN-4040, EN-4060, EN-6080

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For larger sizes, check out Revita® Burn Clear.

Product Information

Sheet format   |   Shelf-stable for up to five (5) years

Sizes   |   10x10 cm

Product Codes    |    RU-1010

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Revita Burn Clear Box

For more application and use information, please see the Instructions for Use.

  1. Oxford Languages. (n.d.). Oxford Advanced Learner’s Dictionary. Retrieved March 01, 2022, from https://languages.oup.com/google-dictionary-en/.
  2. Data on file. The data is reported as an average.
  3. Silini, A. R., Cargnoni, A., Magatti, M., Pianta, S., & Parolini, O. (2015). The Long Path of Human Placenta, and Its Derivatives, in Regenerative Medicine. Frontiers in Bioengineering and Biotechnology3(162). https://doi.org/10.3389/fbioe.2015.00162.
  4. Roy, A., & Griffiths, S. (2020). Intermediate Layer Contribution in Placental Membrane Allografts. Journal of Tissue Engineering and Regenerative Medicine14(8), 1126–1135. https://doi.org/10.1002/term.3086.

Patents: www.stimlabs.com/patents