A lyophilized complete human placental membrane allograft

The use of placental tissues in wound care has been documented in medical texts since the early 20th century.⁴ There are three distinct layers that make up this membrane: the amnion layerThe amnion layer is the innermost layer of the placental membrane. This layer provides tensile strength and acts as a fibrous skeleton.³, intermediate layerThe intermediate layer exists between the amnion and chorion layers and is rich in collagens, proteoglycans, and glycosaminoglycans, like hyaluronic acid.³, and chorion layerThe chorion layer is the outermost, thickest layer of the placental membrane. It contributes to elasticity and membrane stability.³.³ The three layers function together to create the ideal protective covering and barrier between the mother and the fetus.

While most placenta-based products provide single or dual layer allografts, StimLabs has developed the first membrane allograft to retain all three layers of the membrane, including the intermediate layer.² The preserved intermediate layer is a vital part of the membrane barrier property intrinsic to the tissue. The layer contributes to the overall composition of the allograft, containing extracellular matrix components like collagenProvides strength and structural resistance to degrading enzymes in native placental tissue.³, proteoglycansPromotes tissue hydration in native placental tissue.³, and glycosaminoglycans, like hyaluronic acidProvides lubricating and elastic properties in native placental tissue.³.³